產(chǎn)品名稱：sAPP-beta Wild Type ELISA
產(chǎn)    地：Demeditec 
產(chǎn)品貨號：JP27732
產(chǎn)品規(guī)格：96 Tests
產(chǎn)品說明：
Special remarks: This testkit replaces the old version coded JP27722 beginning of 2010.
Cross reactivity with sAPP beta Swedish Type 0.25%, with sAPP-alpha 1.41%.
Alzheimer’s disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1906 and is considered as a major factor of dementia.  It is known that Amyloid beta (A-beta; which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by beta-secretase and subsequent gamma-secretase. The production of soluble APP-beta (sAPP-beta) by beta-secretase cleavage corresponds to A-beta production accordingly, so it is desired to measure sAPP-beta in parallel with A-beta. In addition, it is reported that APP gene mutation exists in early-onset familial Alzheimer's disease patient.  Swedish mutation, one of the APP gene mutations, is a double mutation at positions -1 to -2 from the beta-secretase cleavage site (Lys670 --> Asn and Met671 --> Leu).  And further, it is reported that Swedish mutation elevates A-beta 40 and A-beta 42 production, and that the mutation is utilized in establishment of transgenic mice.  The measuring sAPP in Swedish type is useful for research of AD as well as in Wild type.
On the one hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by alpha-secretase rather than beta-secretase normally to produce soluble APP-alpha and subsequently P3 is cleaved from the remaining C-terminal fragment by gamma-secretase.  In recent research, there are several attempt to apply the inhibitor of beta-secretase and the activation of alpha-secretase for AD treatment. As stated above, it is useful for research of AD to measure sAPP-alpha as well as sAPP-beta (Wild Type, Swedish Type).  This kit can measure sAPP-beta Wild Type.
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