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產(chǎn)品資料

Endothelin-1 ELISA

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產(chǎn)品名稱(chēng): Endothelin-1 ELISA
產(chǎn)品型號(hào): JP27165
產(chǎn)品展商: 原裝進(jìn)口
產(chǎn)品文檔: 無(wú)相關(guān)文檔

簡(jiǎn)單介紹

Endothelin-1 ELISA


Endothelin-1 ELISA  的詳細(xì)介紹
Endothelin-1 ELISA

產(chǎn)品名稱(chēng):Endothelin-1 ELISA
產(chǎn)    地:Demeditec 
產(chǎn)品貨號(hào):JP27165
產(chǎn)品規(guī)格:96 Tests
其它產(chǎn)品:
Endothelin-1 (Big)  Demeditec JP27168 96 Tests 9218
Endothelin-3 Demeditec JP27169 96 Tests 9218
產(chǎn)品說(shuō)明:
Special remarks:
Can be used for humans but also for bovine, canine, murine, porcine, rabbit, rat investigations, as the amino acid sequence of Endothelin-1 in these animals is the same like in humans.
Cross rectivity to Endothelin-3 is 0,1%, all other Endothelins < 0,1%
Endothelin-1 (ET-1), a peptide of 21 amino acid residues, is the most potent vasoconstrictor substance known.  The discovery by Rubanyi’s group in 1985 of a peptide termed endothelium-derived contracting factor (EDCF) and the isolation, sequencing, cloning and naming endothelin by Yanagisawa of the most potent vasoconstrictor has led to more understanding of many physiological effects.  ET-1 is known to be one of a family of three mammalian vasoactive peptides including endothelin-2 (ET-2) and endothelin-3 (ET-3).  These related peptides differ from ET-1 at the two and six amino acid residue positions, respectively.  Those genes make three pre-propeptides that are cleaved into three big endothelin molecules, each 39 amino acid long.  A number of reviews of function, molecular biology of the endothelin family of peptides and propeptides are available.  ET-1 has been shown to have potent effects on smooth muscle cells, fibroblasts and to be involved in many disease processes, particularly cardiovascular diseases.  It has been shown to be important in congestive heart failure, renal failure and pulmonary hypertension.
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