產(chǎn)品名稱：Resistin ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號(hào)：DEE050 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說(shuō)明： Special remarks: INTRODUCTION Resistin, a cysteine-rich protein of 11.3 kDa, was firstly found in mice and constitutes together with RELMa, RELMb and RELMg the protein family of resistin-like molecules (RELM). In humans, resistin and RELMb but no other proteins of the RELM family were found. The human form of resistin shows a homology of 53% to the murine protein. It has 11 cysteine-residues, is synthesized as a propetide of 108 amino acids and secreted as a dimer, build by a disulfide bridge of cysteine residues. Beside this intermolecular disulfide bridge, 5 additional intramolecular ones exist. Appearance of multi- and oligomer formation was proved by size exclusion chromatography. Thereby it was shown, that oligomer formation is SDS-insensitive but can be inhibited by β-mercaptoethanol and is therefore likely to be caused by disulfide bridges. Further on, the resistin structure seems to be dependent on its concentration, as circular dichroism analysis shows a concentration dependent shift of a-helical to b-sheet structure. Resistin expression was demonstrated in white adipose tissue, pituitary and pancreatic islets of mice as well as in brown adipose tissue of rats. In humans, resistin expression in adipocytes can be detected but only at a very low level. But in vitro, resistin expression of non-adipocytes in fatty tissue was shown. Human resistin gene is also expressed in pancreatic islets , pre-adipocytes marcophages and bone marrow. So, resistin is of relevance for inflammation processes as well as for lipid metabolism. 上海玉博生物技術(shù)有限公司在為生命科學(xué)領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于****地位，公司提供的產(chǎn)品涵蓋了二十多個(gè)國(guó)家近五十萬(wàn)種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長(zhǎng)和更新，公司提供的產(chǎn)品能夠使生命科學(xué)工作者加快對(duì)生物化學(xué)，分子生物學(xué)，細(xì)胞生物學(xué)以及蛋白質(zhì)組學(xué)研究的認(rèn)知，以及分子診斷和臨床醫(yī)學(xué)領(lǐng)域的應(yīng)用。
滬公網(wǎng)安備 31011002002623號(hào)
