產(chǎn)品名稱：RNP 70 Ab ELISA 產(chǎn) 地：Demeditec 產(chǎn)品貨號：DE7490 產(chǎn)品規(guī)格：96 Tests 產(chǎn)品說明： Special remarks: Anti-RNP 70 is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against RNP 70 in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Systemic Lupus Erythematosus (SLE) and Mixed connective tissue disease (MCTD). Overlap syndrome is a generic term coined to combine several inflammatory rheumatic diseases characterized by overlapping symptoms of systemic lupus erythematosus (SLE), progressive systemic scleroderma (PSS), Dermato/Polymyositis (DM/PM), rheumatoid arthritis (RA), or Sjögren's syndrome. Mixed connective tissue disease (MCTD) is a serologically well defined overlap syndrome characterized by typical clinical manifestations, distinct autoantibodies specificities and characteristic HLA constellation (i.e. DR2 and DR4). Outstanding clinical manifestation of patients suffering from MCTD is Raynaud's phenomenon with swollen fingers and hands. Additionally, the patients exhibit arthritic complaints. During the course of disease different symptoms of the distinct overlapping connective tissue diseases often emerge in patients suffering from MCTD. However, not all MCTD patients suffer those transitions. Serologically MCTD is characterized by the presence of autoantibodies directed against the 70 kDa protein (also named 60 kDa protein) of the U1-snRNP-Komplex. Up to 100% of MCTD patients manifest high titers of Anti-RNP-70 antibodies. Patients exhibiting only Anti-RNP-70 among the various antinuclear autoantibodies show the classical clinical manifestations of mixed connective tissue disease. Additionally, often SLE typical autoantibodies (e.g. Anti-dsDNA, Anti-Sm, Anti-Histone) come along in the sera of those patients. In these cases classical MCTD will proceed to SLE. The U1-snRNP molecule (its function is splicing of pre-messenger RNA) consists of a uridine rich RNA complexed with the classical RNP antigens, i.e. 70 kDa protein, protein A (33 kDa) and protein C (22 kDa). Also the Sm specific proteins are associated with this RNA. Anti-Sm antibodies are pathognomonic markers for SLE. In the DEMEDITEC Anti-RNP-70 ELISA the wells are exclusively coated with the 70 kDa protein of the U1-snRNP complex. Accordingly, this assays provides the highly specific detection of mainly MCTD associated Anti-RNP-70 autoantibodies. 上海玉博生物技術(shù)有限公司在為生命科學領(lǐng)域提供豐富的產(chǎn)品與信息資源方面處于****地位，公司提供的產(chǎn)品涵蓋了二十多個國家近五十萬種產(chǎn)品，而且產(chǎn)品的數(shù)量與信息在不斷的增長和更新，公司提供的產(chǎn)品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質(zhì)組學研究的認知，以及分子診斷和臨床醫(yī)學領(lǐng)域的應用。
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