產品名稱：ANCA-C (PR3) ELISA 產 地：Demeditec 產品貨號：DE7060 產品規(guī)格：96 Tests 產品說明： Special remarks: Anti-PR3 is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against proteinase 3 (PR3) in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of certain autoimmune vasculitides such as Wegener´s granulomatosis. Anti-neutrophilic-cytoplasm antibodies (ANCA) represents a group of autoantibodies directed towards the cytoplasmatic components of the neutrophilic granulocytes and monocytes. The classical methods for the determination of ANCA are the immunofluorescent methods. With these indirect immunofluorescence techniques two main patterns are recognized, a cytoplasmatic (c-ANCA) and a perinuclear (p-ANCA) type. The main antigen for the c-ANCA is the proteinase 3 (PR3), which is a serine proteinase of the present in primary granules. Antibodies of p-ANCA positive sera are mainly directed to myeloperoxidase (MPO). Antibodies to other antigens e.g. lactoferrin, elastase, cathepsin-G and also lysozyme often result in a similar p-ANCA pattern. Beside different untypical variants of p-ANCA IF patterns granulocyte specific antinuclear antibodies (GS-ANA) is indistinguishable from p-ANCA. This makes a clear interpretation and classification of the IF patterns difficult. Therefore every positive IF-ANCA findings esp. p-ANCA should be differenciated by ELISA techniques using purified antigens. A survey of documented clinical indications of specific ANCA is given in the table below. PR3-ANCA and MPO-ANCA are reliable serologic markers in the diagnostics of vasculitides. PR3-ANCA is the classical autoantigen in Wegener´s granulomatosis with a clinical specificity of more than 95%. c-ANCA is documented to be present in different diseases. The target antigen myeloperoxidase is mainly present (70%) in microscopic polyangiitis. 上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數(shù)量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫(yī)學領域的應用。
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