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DHEA-S RIA

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產(chǎn)品名稱: DHEA-S RIA
產(chǎn)品型號: DE44100
產(chǎn)品展商: 原裝進(jìn)口
產(chǎn)品文檔: 無相關(guān)文檔

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DHEA-S RIA


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DHEA-S RIA

產(chǎn)品名稱:DHEA-S RIA
產(chǎn)    地:Demeditec 
產(chǎn)品貨號:DE44100
產(chǎn)品規(guī)格:100 Tests
產(chǎn)品說明:
Special remarks:
Dehydroepiandrosterone sulphate (DHEA-SO4) is almost exclusively synthesized by the adrenal cortex, and it is the most abundant steroid hormone in the peripheral circulation. It is the main source of the urinary 17-ketosteroids. The metabolic clearance of DHEA-SO4 is slow, and it is converted mostly to oestrogens. The hormone has a maximum level from puberty until 20-30 years of age, then there is a gradual decrease in the blood DHEA-SO4 concentration mainly in the menopause of women. Although the physiological role of DHEA?SO4 is not well established the serum level of this steroid hormone has an informative pathophysiological value.
1.The serum DHEA-SO4 radioimmunoassay seems to be a reliable tool to assess adrenal androgen function and the glandular overproduction of androgens.
2.High DHEA-SO4 values indicate a virilizing disorder of adrenal origin in women. This includes mainly adrenal neoplasms or early or late onset of congenital adrenal hyperplasia.
3.Monitoring the DHEA-SO4 concentration may be useful to control the adrenal suppressive therapy (dexamethasone).
4.Low DHEA-SO4 levels can be an indicator of hormone-dependent immunological disorders.
5.Low levels of DHEA-SO4 may be related to the development of diseases that increases with age such as cancer and atherosclerosis. In these circumstances a systematically repeated assessment of the blood DHEA-SO4 values is recommended.
There is also a method available for the measurement of free DHEA in saliva. The metabolic activity of any steroid is just represented by the free hormone fraction which represents less than 5% of the total. The non-invasive sampling of saliva samples offers another advantage of salivary testing. Demeditec is offering such a testkit in ELISA format with the catalogue number  DESLV3012.
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