PAPP-A IRMA

產品名稱：PAPP-A IRMA
產    地：Demeditec 
產品貨號：DE42100
產品規格：100 Tests
產品說明：
Special remarks:
Introduction
Pregnancy-associated plasma protein A is a large placenta-derived glycoprotein. The biological function of PAPP-A is not completely known, it has been shown its proteolytic and immuno-regulating action through cleavage of insulin-like growth factor binding protein 4. PAPP-A maternal serum concentration rises during pregnancy. Measurement of PAPP-A, in conjunction with other parameters (free ßhCG concentration, fetal ultrasound, maternal age) can be used in the risk assessment of Down’s syndrome during the first trimester of pregnancy. Mostly, values under 0.5 MOM (multiple of median) are considered pathological, however, isolated PAPP-A data have no diagnostic value by itself.  For screening use, a computerized (parameter-weighted) interpretation of results is necessary with validated software. Each laboratory should determine its own reference (MOM) values.
Principle of method
This technology uses two high affinity monoclonal antibodies in an immunoradiometric assay (IRMA) system. The 125I labelled signal-antibody binds to an epitope of the PAPP-A molecule spatially different from that recognized by the biotin-capture-antibody. The two antibodies react simultaneously with the antigen present in standards or samples, which leads to the formation of a capture antibody - antigen - signal antibody complex, also referred to as a “sandwich”. During 2-hours incubation period with shaking, immuno-complex is immobilized to the reactive surface of streptavidin coated test tubes. Reaction mixture is then discarded, test tubes washed exhaustively, and the radioactivity is measured in a gamma counter. The concentration of antigen is directly proportional to the radioactivity measured in test tubes. By constructing a calibration curve plotting binding values against a series of calibrators containing known amounts of PAPP-A, the unknown concentration of PAPP-A in patient samples can be determined.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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