Oxytocin

產品名稱：Oxytocin ELISA
產    地：Demeditec 
產品貨號：DE3117
產品規格：96 Tests
產品說明：
Special remarks:
FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
1 Description
The Oxytocin ELISA kit is a competitive immunoassay for the quantitative determination of Oxytocin in samples.
The kit uses a polyclonal antibody to Oxytocin to bind, in a competitive manner, the Oxytocin in the standard or sample or an alkaline phosphatase molecule which has Oxytocin covalently attached to it. After a simultaneous incubation at 4°C the excess reagents are washed away and substrate is added. After a short incubation time the enzyme reaction is stopped and the yellow color generated read on a microplate reader at 405 nm.
The intensity of the bound yellow color is inversely proportional to the concentration of Oxytocin in either standards or samples. The measured optical density is used to calculate the concentration of Oxytocin.
For further explanation of the principles and practice of immunoassays please see the excellent books by Chard or Tijssen.
2 Introduction
Oxytocin is a neurohypophysial peptide which is produced in the paraventricular nuclei of the hypothalamus and stored in the posterior pituitary. The molecule consists of nine amino acids linked with a [1-6] disulfide bond and a semi-flexible carboxyamidated tail. A hormone once thought to be limited to female smooth muscle reproductive physiology , more current findings have determined that oxytocin also functions as a neurotransmitter, may be involved in neuropsychiatric disorders, social/sexual behavior and is important in male reproductive physiology. Oxytocin and the related neurohypophysial peptide, Arg-Vasopressin, maintain renal water and sodium balance.
Oxytocin   H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Highly conserved across species boundaries, oxytocin-like neurohypophysial peptides are substituted primarily at residues 4 and/or 8. In the oxytocin-like peptide, mesotocin, a common peptide found in some fishes, reptiles, amphibians, marsupials and nonmammalian tetrapods, the leucine at residue 8 is substituted for isoleucine8. Acting in classical endocrine fashion, Oxytocin elicits regulatory effects by binding specific cell surface receptors which in turn initiate a secondary intracellular response cascade via a phosphoinositide signaling pathway.
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