產(chǎn)品名稱：K252a 產(chǎn)品貨號：Affix AF3065 產(chǎn)品規(guī)格：1 mg Technical Data Chemical Name 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-. Biological Description K252a inhibits a variety of kinases including PKC (IC50 = 25 nM), PKA (IC50 = 18 nM) and PKG (IC50 = 20 nM)1. It also inhibits CaMK (IC50 = 1.8 nM) and MLCK (IC50 = 17 nM). K252a has also been shown to inhibit NGF mediated proliferation through Trk receptor family2. Molecular Weight 467 daltons Molecular Formula C27H21N3O5 Solubility Soluble in DMSO (1 mg/ml) and DMF (1 mg/ml) Purity >98 % Storage instructions Up to one week at 4°C or six months at -20°C. CAS No. 97161-97-2 References Tapley, P. et al. (1992) Oncogene 7, 371.
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