產(chǎn)品名稱：Terfenadine 產(chǎn)品貨號(hào)：Affix AF3057 產(chǎn)品規(guī)格：50 mg Technical Data Chemical Name α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol Biological Description Terfenadine is a Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo . Molecular Weight 471.6 daltons Molecular Formula C32H41NO2 Solubility Soluble in Chloroform Purity >98% Storage instructions Up to one week at 4°C or six months at -20°C. CAS No. 50679-08-8 References Crumb, W.J., 2000. J. Pharmacol. Exp. Ther. 292: 261-264.
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