產(chǎn)品名稱：Vorinostat 產(chǎn)品貨號：Affix AF3047 產(chǎn)品規(guī)格：100 mg Technical Data Chemical Name N1-hydroxy-N8-phenyl-octanediamide Biological Description Vorinostat ,Suberoylanilide hydroxamic acid (SAHA). is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. Molecular Weight 264.3 daltons Molecular Formula C14H20N2O3 Solubility Soluble in Methanol and DMSO Purity >98% Storage instructions Up to one week at 4°C or six months at -20°C. CAS No. 149647-78-9 References Munster, P.N., et al. 2001. Cancer Res. 61
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