產(chǎn)品名稱：Fludarabine 產(chǎn)品貨號：Affix AF3036 產(chǎn)品規(guī)格：25 mg Technical Data Chemical Name 9-β-D-Arabinofuranosyl-2-fluoro-9H-p urin-6-amine Biological Description Fludarabine is a organic compound (purine analog) that inhibits DNA synthesis.Exhibits antiproliferative activity (IC50 < 3 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo. Fludarabine (Fludara) can also induce pro-inflammatory stimulation of monocytic cells, as evaluated by increased expression of ICAM-1 and IL-8 release. Molecular Weight 285.2 daltons Molecular Formula C10H12FN5O4 Solubility Soluble in DMSO Purity >99 % Storage instructions Up to one week at 4°C or six months at -20°C. CAS No. 21679-14-1 References Torella et al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935.
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