產品名稱：Fludarabine
產品貨號：Affix  AF3036
產品規格：25 mg
Technical Data
Chemical Name 9-β-D-Arabinofuranosyl-2-fluoro-9H-p urin-6-amine
Biological Description Fludarabine is a organic compound (purine analog) that inhibits DNA synthesis.Exhibits antiproliferative activity (IC50 < 3 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo. Fludarabine (Fludara) can also induce pro-inflammatory stimulation of monocytic cells, as evaluated by increased expression of ICAM-1 and IL-8 release.
Molecular Weight 285.2 daltons
Molecular Formula C10H12FN5O4
Solubility Soluble in DMSO
Purity >99 %
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No. 21679-14-1 
References Torella et al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935.

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