產(chǎn)品名稱：Topiramate 產(chǎn)品貨號(hào)：Affix AF3017 產(chǎn)品規(guī)格：50 mg Technical Data Chemical Name 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate Biological Description Topiramate is an Anticonvulsant. Antagonizes GluR5 kainate receptors (IC50 = 0.46 μM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Topiramate is also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH. Molecular Weight 339.3 daltons Molecular Formula C21H21NO8S Solubility Soluble in DMSO (44 mg/ml) and in ethanol Purity >98% Storage instructions Store at -20°C CAS No. 97240-79-4 References Ben-Menachem, E., Sander, J.W., Stefan, H., et al. Topiramate monotherapy in the treatment of newly or recently diagnosed epilepsy. Clin Ther 30(7) 1180-1195 (2008).
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