產品名稱：Stauprimide
產品貨號：LC  S-9344
產品規格：10 MG
Stauprimide increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs).  Stauprimide binds to NME2 and inhibits its nuclear localization, thus leading to downregulation of c-Myc.  Zhu, S., et al.  "A small molecule primes embryonic stem cells for differentiation."  Cell Stem Cell 4:  416-426 (2009).
Stauprimide interacts with NME2, a c-Myc-activating transcription factor that is highly expressed in ESCs.  Stauprimide treatment inhibits the nuclear localization of NME2 and downregulates c-Myc, enhances ESC exit from the pluripotent state and enables differentiation.  Zaret, K.  "Using Small Molecules to Great Effect in Stem Cell Differentiation."  Cell Stem Cell 4:  373-374 (2009).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

產品留言

標題

聯系人

聯系電話

內容

驗證碼

點擊換一張

注：1.可以使用快捷鍵Alt+S或Ctrl+Enter發送信息!
2.如有必要,請您留下您的詳細聯系方式!