產品名稱：PIK-75, Hydrochloride Salt
產品貨號：LC  P-7050
產品規格：100 MG
PIK-75 is a preferential inhibitor of the p110α/γ forms of phosphatidylinositol 3-kinase (PI3K), which comprise a class of lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3).  PIP3 activates Akt and mTOR, and plays important roles in cell growth and survival.
PIK-75-mediated anti-inflammatory effects are associated with dramatic inhibition of AKT phosphorylation, IKK activation and NF-κB transcription.  Dagia, N.M., et al.  "A Preferential p110α/γ PI3K Inhibitor Attenuates Experimental Inflammation by Suppressing the Production of Proinflammatory Mediators in NF-κB Dependent Manner."  Am. J. Physiol. Cell Physiol. 298:  C929-C941 (2010).
PIK-75 completely inhibited adipocyte differentiation.  Kim, J.E., et al.  "Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation."  Biochem. Biophys. Res. Commun. 379:  830-834 (2009).
Insulin-like growth factor-1 (IGF-1) potentiates PAR-1-mediated platelet aggregation.  PIK-75 and PI-103 completely inhibited this potentiation, indicating PI3Kα; is essential for the enhancement by IGF-1 of platelet responses.  Hers, I.  "Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway."  Blood 110:  4243-4252 (2007).
In addition to the p110α isotype of PI3K , p110β and p110δ can also play a role in insulin signalling.  Chaussade, C., et al.  "Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling."  Biochem. J. 404:  449-458 (2007).
Our PIK-75 product, whose CAS number appears above, is the hydrochloride salt.  The CAS number for the free base is 372196-67-3.
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Disposal:  A

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