Brefeldin A **

產品名稱：Brefeldin A
產品貨號：LC  B-8500
產品規格：100 MG
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.  Misumi, Y., et al.  "Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes."  J. Biol. Chem. 261:  11398-11403 (1986).
Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation.  Guo, H., et al.  "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2."  Exp. Cell Res. 245:  57-68 (1998).
Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle.  Linardic, C. M., et al.  "Activation of the sphingomyelin cycle by brefeldin A:  effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking."  Cell Growth Differ. 7:  765-774 (1996).  Alessenko, A.V.  "The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death."  Membr. Cell Biol. 13:  303-320 (2000).
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Warning:  Toxic.
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 100 mg/mL; soluble in ethanol at 25 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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