Irinotecan HCl trihydrate **

產品名稱：Irinotecan HCl trihydrate
產品貨號：LKT  I6933
產品規格：10mg 
Description
Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.
Specifications 
Cas No. 136572-09-3
Product ID  I6933
Product Name  Irinotecan HCl trihydrate
Chemical Name  [1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11- diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
Synonym Irinotecan hydrochloride trihydrate; Camptosar; Campto
Formula Wt. 677.19
Melting Point 256.5oC
Purity ≥98% 
Solubility Slightly soluble in water, ethanol, chloroform.
Store Temp Ambient
References Kellner U, Rudolph P, Parwaresch R. Onkologie. 23:424-430 (2000). Kalemkerian GP, Worden FP. Expert Opin Investing Drugs. 9:565-79 (2000). Saltz LB. Curr Oncol Rep. 1:155-160 (1999).

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