產(chǎn)品名稱：anti-mouse CD86 eFluorTM 605nm GL1 100 tests 產(chǎn)品貨號(hào)：eBioscience 93-0862-42 產(chǎn)品規(guī)格：100 tests Anti-Mouse CD86 (B7-2) eFluor® 605NC Also known as: B72, B7.2, B70, Ly-58 Clone: GL1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 93-0862 Cat. No. Size 93-0862-41 25 tests 93-0862-42 100 tests Description: The GL1 monoclonal antibody reacts with mouse CD86, an ~80 kDa surface receptor also known as B7-2. CD86 & CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). This interaction plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation, supports its major contribution during the primary phase of an immune response.
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