產品名稱：CaspGLOW Fluorescein Active Caspase Staining Kit 產品貨號：eBioscience 88-7003-42 產品規(guī)格：100 tests CaspGLOW™ Fluorescein Active Caspase Staining Kit RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 88-7003 Cat. No. Size 88-7003-42 100 tests Description: The CaspGLOW Fluorescein Active staining kit contains the reagents to sensitively detect active caspase in all mammalian cells. This assay utilizes the inhibitor specific for all caspases, Z-VAD-FMK, that is directly conjugated to FITC (fluorescein isothiocyanate) for the detection system. This reagent is cell permeable, non-toxic and irreversibly binds to the active enzyme. Detection of the labeled cells can be determined by flow cytometry, fluorescent microscopy or a fluorescent plate reader. The Caspases are a family of aspartate-specific cysteine proteases that act in a step-wise signaling manner like kinases. Recruitment of these proteases to oligomerized receptors leads to activation and autoproteolytic cleavage. Active caspases can proteolyze additional caspases generating a caspase cascade. The final outcome of this signaling pathway is a form of controlled cell death, termed apoptosis.
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