Alexa Fluor® 488 anti-human CD317 (BST2) **

產品名稱：Alexa Fluor® 488 anti-human CD317 (BST2) 100 tests
產品貨號：eBioscience 53-3179-42
產品規格：100 tests
Anti-Human CD317 (BST2, PDCA-1) Alexa Fluor® 488
Also known as: plasmacytoid DC Ag-1, pDC Ag-1, BST 2, PDCA1
Clone: 26F8
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 53-3179
Cat. No. Size
53-3179-41  25 tests 
53-3179-42  100 tests 
Description: This 26F8 monoclonal antibody reacts with human CD317 (also known as BST2 and tetherin). CD317 is a 30-36-kDa type II transmembrane protein expressed on B cells and bone marrow stromal cells. Although reports have indicated that CD317 mRNA is detectable in activated T cells, protein expression in freshly isolated primary T cells and macrophages is undetectable. Moreover, certain T cell lines, such as Jurkat, do not express detectable levels of CD317 protein. However, CD317 expression can be induced in many cell types (e.g., T and B cells, 293T, and HeLa) by IFNα treatment. CD317 has been associated with pre-B cell growth and the terminal differentiation of plasma B cells. More recently, this molecule has been reported to prevent HIV-1 virion release from the surface of infected cells, leading to reuptake and degradation of the virus. This activity is inhibited by the HIV-1 accessory protein Vpu. CD317 has been identified as the ligand for the ILT7 receptor.

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