PerCP-e710 Human CD38 (clone HB7), **

產品名稱：PerCP-e710 Human CD38 (clone HB7), 100 tests
產品貨號：eBioscience 46-0388-42
產品規格：100 tests
Anti-Human CD38 PerCP-eFluor® 710
Also known as: ADP-Ribosyl Cyclase, Cyclic ADP-Ribose Hydrolase
Clone: HB7
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 46-0388
Cat. No. Size
46-0388-41  25 tests 
46-0388-42  100 tests 
Description: The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. CD38 is an ectoenzyme which catalyses NAD into nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR), both of which are secondary messengers. Expression of CD38 is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. Additionally CD38 is found in a variety of tissues and other hematopoietic cells (e.g. T cells, NK cells and monocytes) and can be used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38- population of hematopoietic stems cells is thought to define the most pluripotent cells (e.g. blast colony forming cells). In addition to surface expression, CD38 has recently been found in the nucleus where it may play a role in monitoring calcium levels.

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