Human CD79a (clone HM47), **

產品名稱：Human CD79a (clone HM47), 100 tests
產品貨號：eBioscience 45-0792-42
產品規格：100 tests
Anti-CD79a PerCP-Cy5.5
Also known as: Ig-alpha, mb-1
Clone: HM47
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 45-0792
Cat. No. Size
45-0792-41  25 tests 
45-0792-42  100 tests 
Description: The monoclonal antibody HM47 recognizes the cytoplasmic domain of CD79a, also known as mb-1. CD79a is a 47 kDa membrane glycoprotein that associates with CD79b to form the heterodimeric B cell receptor (BCR). This receptor is responsible for B cell signaling, resulting in activation, apoptosis or anergy. Expression of CD79a is found throughout development from the earliest pre-B cell to plasma cells. CD79 is expressed on B cell neoplasms and some non-B cell malignancies such as AML. Unlike other antibodies that can be masked in B cell neoplastic cells, HM47 is a reliable antibody for recognizing CD79a and, as such, is a good marker for B cells. Because several variants of CD79a exist, the exact location of the epitope may differ slightly. Nevertheless, in humans thie epitope is typically amino acids 208-222.
The HM47 antibody reacts to human, mouse, rat, dog, primates (rhesus, chimpanzee, macaque and baboon) pig, guinea rabbit, pig, horse, cow and chicken.

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