Rat IL-17A/F Recombinant Protein Carrier Free **

產品名稱：Rat IL-17A/F Recombinant Protein Carrier Free 500 ug
產品貨號：eBioscience 34-8217-85
產品規格：500 ug
Rat IL-17AF Recombinant Protein Carrier-Free
Also known as: Interleukin-17AF, IL-17A/F, IL17A/F
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 34-8217
Cat. No. Size
34-8217-82  100 ug 
34-8217-85  500 ug 
Description: IL-17A and IL-17F are members of the IL-17 family of proinflammatory cytokines. They share 50% amino acid sequence homology, which is the highest within the group. Both cytokines exist as homodimers although the individual subunits from each protein can also associate into a heterodimer known as IL-17AF.
Expression of IL-17A, F, and AF is most often associated with the Th17 subset of CD4+ T cells, but has also been observed in NKT cells and γδ T cells. They play an important role in the activation of neutrophils and induce inflammatory cytokine production in epithelial cells, endothelial cells, macrophages, and fibroblasts through NF-κB signaling. The heterodimer displays bioactivity intermediate to that of the two homodimers, with IL-17A being the most potent. IL-17AF and Th17 cells have been implicated in various autoimmune disorders, including rheumatoid arthritis, psoriasis, irritable bowel syndrome, and asthma.

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