Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free, **
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產品名稱: Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free, **
產品型號: 34-8000-85
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Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free, **
Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free, **
的詳細介紹
Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free, **
產品名稱：Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free, 500 ug
產品貨號：eBioscience 34-8000-85
產品規格：500 ug
Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free
Also known as: C-C motif Chemokine 3, Macrophage Inflammatory Protein-1 alpha
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 34-8000
Cat. No. Size
34-8000-82 100 ug
34-8000-85 500 ug
Description: CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 are chemoattractant for monocytes, macrophages, and dendritic cells, CCL3 preferentially attracts CD8+ T cells, while CD4+ T cells are more responsive to CCL4. In addition to its chemotactic functions, CCL3 induces inflammatory cytokine secretion, mast cell degranulation, and NK cell activation. It has also been reported to inhibit hematopoetic stem cell proliferation and may be responsible for the maintenance of these cells in a quiescent state.
CCL3 signaling is mediated by the G protein-coupled receptor, CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which it binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.
