Phycoerythrin-Cy7 (PE-Cy7) anti-mouse KLRG1/MAFA **

產品名稱：Phycoerythrin-Cy7 (PE-Cy7) anti-mouse KLRG1/MAFA 100 ug
產品貨號：eBioscience 25-5893-82
產品規格：100 ug
Anti-Mouse KLRG1 PE-Cy7
Also known as: MAFA
Clone: 2F1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 25-5893
Cat. No. Size
25-5893-80  25 ug 
25-5893-82  100 ug 
Description: This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38 kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.

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