產(chǎn)品名稱：Anti-Human Podoplanin APC (NZ-1.3) 100 tests 產(chǎn)品貨號：eBioscience 17-9381-42 產(chǎn)品規(guī)格：100 tests Anti-Human Podoplanin APC Also known as: PDPN Clone: NZ-1.3 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-9381 Cat. No. Size 17-9381-41 25 tests 17-9381-42 100 tests Description: Podoplanin is a 40-kDa type I transmembrane sialomucin-like glycoprotein involved in platelet aggregation and cancer metastasis. This protein is expressed on lymphatic endothelial cells and follicular dendritic cells, as well as on many human cancers, including squamous cell carcinoma, glioblastoma, seminoma, and mesothelioma. Podoplanin expression has been demonstrated to be regulated by the Fos protein of the Activating Protein-1 (AP-1) transcription factor complex. Much of its functionality arises via interaction with its endogenous receptor, C-type lectin-like receptor-2 (CLEC-2). This antibody has been reported to block the interaction between Podoplanin and CLEC-2.
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