產(chǎn)品名稱：Anti-Mouse CD200 Receptor APC (OX110) 100 ug 產(chǎn)品規(guī)格：eBioscience 17-5201-82 產(chǎn)品貨號：100 ug Anti-Mouse CD200 Receptor APC Also known as: CD200R, OX2R Clone: OX110 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-5201 Cat. No. Size 17-5201-80 25 ug 17-5201-82 100 ug Description: The monoclonal antibody OX110 recognizes mouse CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFα secretion. Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells.
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