產(chǎn)品名稱：APC Human CD172a (clone 15-414), 100 tests 產(chǎn)品規(guī)格：eBioscience 17-1729-42 產(chǎn)品貨號(hào)：100 tests Anti-Human CD172a (SIRP alpha) APC Also known as: SIRPa, SHPS-1 Clone: 15-414 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-1729 Cat. No. Size 17-1729-41 25 tests 17-1729-42 100 tests Description: This 15-414 monoclonal antibody reacts with human CD172a, also known as signal regulatory protein alpha (SIRP alpha). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, granulocytes, dendritic cells, and CD34+CD38- hematopoietic progenitor cells but not on T and B lymphocytes. Moreover, neurons have also been shown to express CD172. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.
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