產(chǎn)品名稱：APC Human CD162 (clone FLEG), 100 tests 產(chǎn)品規(guī)格：eBioscience 17-1629-42 產(chǎn)品貨號(hào)：100 tests Anti-Human CD162 (PSGL-1) APC Also known as: PSGL1, PSGL-1 Clone: FLEG RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-1629 Cat. No. Size 17-1629-41 25 tests 17-1629-42 100 tests Description: This FLEG monoclonal antibody recognizes human CD162, which is also known as P-selectin glyocoprotein ligand-1 (PSGL-1). This 120-kDa protein exists as a homodimer on the surface of monocytes, neutrophils, granulocytes, peripheral T cells, some B cells, and a subset of CD34+ hematopoietic progenitor cells (HPCs) in the bone marrow. CD162 binds CD62P (P-selectin), CD62E (E-selectin), and CD62L (L-selectin) to mediate leukocyte interactions with each other as well as with activated platelets and endothelium. Thus, CD162 plays a critical role in leukocyte adhesion and rolling. Furthermore, the binding of CD162 to P-selectin on HPCs has been demonstrated to inhibit hematopoiesis. Studies have also demonstrated CD162 as the receptor for enterovirus 71.
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