產(chǎn)品名稱：APC Human CD47 (clone B6H12), 100 tests 產(chǎn)品貨號：eBioscience 17-0479-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD47 APC Also known as: Integrin associated protein, IAP, neurophilin Clone: B6H12 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-0479 Cat. No. Size 17-0479-41 25 tests 17-0479-42 100 tests Description: The monoclonal antibody B6H12 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain. CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 integrins CD51/CD61 and CD41/CD61. Furthermore this interaction can mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex). Expression is also found in non-hematopoietic cells. This antibody has been reported to have neutralizing activity.
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