產(chǎn)品名稱：anti-human CXCR4 (CD184, Fusin) FG Purified 12G5 500 ug 產(chǎn)品貨號：eBioscience 16-9999-85 產(chǎn)品規(guī)格：500 ug Anti-Human CD184 (CXCR4) Functional Grade Purified Also known as: C-X-C chemokine receptor type 4, Fusin, SDF-1 receptor Clone: 12G5 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-9999 Cat. No. Size 16-9999-81 50 ug 16-9999-85 500 ug Description: The 12G5 monoclonal antibody reacts with human CXCR4 (CD184), also termed Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CXCR4 is expressed predominantly on naive T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. 12G5 shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CXCR4), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.
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