產(chǎn)品名稱：Functional Grade human IGF-1R (clone 1H7), 100 ug 產(chǎn)品貨號(hào)：eBioscience 16-8849-82 產(chǎn)品規(guī)格：500 ug Anti-Human CD221 (Insulin-like Growth Factor-1 Receptor) Functional Grade Purified Also known as: IGF-1R Clone: 1H7 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-8849 Cat. No. Size 16-8849-80 25 ug 16-8849-82 100 ug Description: This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression. This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.
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