產(chǎn)品名稱：Anti-Mouse IL-15R/IL-15 Complex Functional Grade Purified (GRW15PLZ), 500 ug 產(chǎn)品貨號：eBioscience 16-8156-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse IL-15/IL-15R Complex Functional Grade Purified Also known as: Interleukin 15, IL15, IL-15 receptor, receptor/ligand complex Clone: GRW15PLZ RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-8156 Cat. No. Size 16-8156-82 100 ug 16-8156-85 500 ug Description: The monoclonal antibody GRW15PLZ recognizes the mouse IL-15/IL-15 receptor complex. Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that is has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the subunits of this receptor, beta and gamma, are shared with the IL-2 receptor, while the alpha subunit is unique to IL-15. Despite the expression of IL-15 mRNA in many cell types, the secreted protein is rarely detectable in biological samples. Recent research suggests that IL-15 is retained inside the cell and is only secreted when in complex with its unique receptor, IL-15R alpha. The cytokine/receptor complex may stay bound to the cell surface, where it can be trans-presented to cells expressing the beta gamma subunits of the receptor, or may be secreted in a soluble form that lacks the transmembrane domain of the receptor. The soluble IL-15/IL-15R complex is produced by mouse dendritic cells, fibroblasts, and macrophages and demonstrates a 10-100-fold increase in agonistic activity over IL-15 alone. The monoclonal antibody GRW15PLZ reacts with and inhibits the bioactivity of IL-15 and the IL-15/IL-15R complex.
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