產(chǎn)品名稱：Anti-Mouse G-CSF (clone 9B4CSF) Functional Grade Purified, 500 ug 產(chǎn)品貨號：eBioscience 16-7353-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse G-CSF Functional Grade Purified Also known as: Granulocyte Colony-Stimulating Factor, CSF-3 Clone: 9B4CSF RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-7353 Cat. No. Size 16-7353-85 500 ug Description: This 9B4CSF monoclonal antibody reacts with mouse G-CSF (Granulocyte Colony-Stimulating Factor), a growth factor that stimulates the proliferation, differentiation, and mobilization of hematopoetic stem cells. It is expressed by monocytes, macrophages, and bone marrow stromal cells, and can also be induced in fibroblasts by IL-17A. Unlike GM-CSF and IL-3, which can stimulate cells of multiple lineages, G-CSF activity is limited to neutrophilic granulocytes. G-CSF is essential to the maintenance of neutrophil counts during homeostasis, and low basal levels of the protein are detectable in the serum of healthy individuals. Circulating levels become elevated rapidly upon infection, as G-CSF is also important for the activation and mobilization of mature neutrophils during the innate immune response. G-CSF therapy is commonly used to treat neutropenia following bone marrow transplant or chemotherapy. This 9B4CSF antibody has been demonstrated to cross-react with human G-CSF. However, it is recommended to use Anti-Human G-CSF Functional Grade Purified (clone 4A4RC, cat. 16-7338) for neutralization of human G-CSF.
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