產(chǎn)品名稱：Anti-Human IL-17F Functional Grade Purified (SHLR17) 500 ug 產(chǎn)品貨號：eBioscience 16-7169-85 產(chǎn)品規(guī)格：500 ug Anti-Human IL-17F Functional Grade Purified Also known as: Interleukin-17F Clone: SHLR17 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-7169 Cat. No. Size 16-7169-82 100 ug 16-7169-85 500 ug Description: This SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F. IL-17F is a homodimeric, 34 kDa member of the IL-17 family, which includes IL-17(A), B, C, D, E (IL-25). Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely. IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well. In vitro cultured Th17 cells have been shown to express IL-17F and IL-17A homodimers and IL-17A/F heterodimers depending on the culture conditions and their differentiation state. A heterodimer of IL-17RA and IL-17RC has been shown to bind IL-17F, resulting in target cell-secretion of pro-inflammatory cytokines and chemokines, as well as neutrophil recruitment. This SHLR17 monoclonal antibody neutralizes the bioactivity of IL-17F homodimers without affecting IL-17A/F heterodimers.
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