產(chǎn)品名稱：anti-human ILT3 (GM 4d, CD85k) FG Purified ZM4.1 500 ug 產(chǎn)品貨號(hào)：eBioscience 16-5139-85 產(chǎn)品規(guī)格：500 ug Anti-Human CD85k (ILT3) Functional Grade Purified Also known as: ILT-3, LIR5, LILRB4, HM18, GM 4d Clone: ZM4.1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-5139 Cat. No. Size 16-5139-81 50 ug 16-5139-85 500 ug Description: The monoclonal antibody ZM4.1 recognizes ILT3, also known as CD85k. ILT3 is a member of the large family of ILT molecules (Immunologulin-like Transcripts, Leucocyte Ig-like Receptors (LIRs) and Monocyte/Macrophage Ig-like Receptors (MIRs). ILT3 is a 60kDa transmembrane protein with two Ig domains and ITIMs. Expression is found on monocytes, macrophages, and dendritic cells. High levels of ILT3 expression is also found on plasmacytoid dendritic cells (pDCs). ILT3 expression by DCs has been shown to be required to induce Regulatory Tcells (tregs). Addition of ZM4.1, like ZM3.8, blocks the suppressive function of the Tregs in in vitro culture systems with allogenic DC’s.
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