產品名稱：anti-mouse CD54 FG Purified eBioKAT-1 (KAT-1, KAT1) 500 ug 產品貨號：eBioscience 16-0542-82 產品規(guī)格：500 ug Anti-Mouse CD54 (ICAM-1) Functional Grade Purified Also known as: Intercellular adhesion molecule-1 Clone: eBioKAT-1 (KAT-1, KAT1) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-0542 Cat. No. Size 16-0542-85 500 ug 16-0542-81 50 ug 16-0542-82 100 ug Description: The eBioKAT-1 monoclonal antibody reacts with mouse CD54 (ICAM-1), which is a 95 kDa member of the immunoglobulin superfamily. CD54 is expressed at low levels on leukocytes and high endothelial venules, and expression increases in response to inflammatory cytokines. ICAM-1 binds to LFA-1 and this interaction is required for the transendothelial migration of T cells. ICAM-1-deficient mice are viable, however the migration of leukocytes to sites of inflammation is reduced leading to impaired immune and inflammatory responses. Based on the regulated expression of ICAM-1, it has been suggested that ICAM-1 may increase leukocyte extravasation at sites of inflammation, whereas the constitutively high expression of ICAM-2 mediates leukocyte traffic into non-inflamed tissue. The eBioKAT-1 monoclonal antibody recognizes a different epitope than the YN1/1.7.4 monoclonal antibody.
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