產(chǎn)品名稱：anti-mouse PD-1 (CD279) Purified RMP1-14 500 ug 產(chǎn)品貨號(hào)：eBioscience 14-9982-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse CD279 (PD-1) Purified Also known as: PD1 Clone: RMP1-14 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9982 Cat. No. Size 14-9982-81 50 ug 14-9982-82 100 ug 14-9982-85 500 ug Description: This antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (cat. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.
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