產(chǎn)品名稱：anti-human MD-2 Purified 9B4 100 ug 產(chǎn)品貨號：eBioscience 14-9928-82 產(chǎn)品規(guī)格：100 ug Anti-Human MD-2 Purified Also known as: MD2 Clone: 9B4 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9928 Cat. No. Size 14-9928-80 25 ug 14-9928-82 100 ug Description: The 9B4 antibody reacts with human MD-2, an approximately 30 kDa molecule, which physically associates with the extracellular domain of TLR4. MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4 since in MD-2(-/-) embryonic fibroblasts, TLR4 was not able to reach the plasma membrane and predominantly resided in the Golgi apparatus, whereas TLR4 was distributed at the leading edge surface of cells in wild-type embryonic fibroblasts. MD-2(-/-) mice do not respond to LPS, do survive endotoxic shock but are susceptible to Salmonella typhimurium infection.
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