產(chǎn)品名稱：anti-human/mouse Fn14/TWEAK Receptor (CD266) Purified ITEM-2 100 ug 產(chǎn)品貨號：eBioscience 14-9016-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse CD266 (TWEAK Receptor) Purified (Discontinued - refer to Cat. No. 14-9018) Also known as: TNFRSF12A, Fibroblast growth factor-inducible 14, Fn14 Clone: ITEM-2 RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: Please refer to alternative clone, Cat. No. 14-9018. SKU# 14-9016 Description: The ITEM-2 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducable 14 kDa protein) and cross-reacts with the mouse antigen. Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1 (Cat. No. 16-9915). Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line. ITEM-2 is reported to act as an antagonist in in vitro functional assays.
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