產品名稱：anti-mouse c-Met (HGFR) Purified eBioclone 4 100 ug 產品貨號：eBioscience 14-8855-82 產品規(guī)格：100 ug Anti-Mouse c-Met (HGF Receptor) Purified Also known as: hepatocyte growth factor receptor, HGFR Clone: eBioclone 4 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8855 Cat. No. Size 14-8855-82 100 ug 14-8855-80 25 ug Description: The eBioclone 4 monoclonal antibody was generated against a mouse c-Met-Ig fusion protein, and reacts with mouse c-Met (HGFR)-transfected cells. Mouse c-Met is a 170 kDa receptor tyrosine kinase (RTK) expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC-γ. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis. Mutations in human c-Met have been implicated in the development of several malignancies. The eBioclone 4 monoclonal antibody has been tested by flow cytometric analysis of mouse c-Met-transfected 293T cells. The low level of expression of mouse c-Met in primary tissue, including bone marrow cells from ***** mice, may make flow cytometric detection of the endogenous c-Met protein difficult. Experiments are underway to evaluate use eBioclone 4 for flow cytometric detection of c-Met from primary cells. Please contact eBioscience technical support for further information.
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