產(chǎn)品名稱：anti-mouse c-Met (HGFR) Purified eBioclone 7 100 ug 產(chǎn)品貨號：eBioscience 14-8854-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse c-Met (HGF Receptor) Purified Also known as: hepatocyte growth factor receptor Clone: eBioclone 7 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8854 Cat. No. Size 14-8854-80 25 ug 14-8854-82 100 ug Description: The eBioclone 7 monoclonal antibody was generated against a mouse c-Met-Ig fusion protein, and reacts with mouse c-Met-transfected cells. Mouse c-Met (HGFR) is a 170 kDa receptor tyrosine kinase (RTK) expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC gamma. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis. Mutations in human c-Met have been implicated in the development of several malignancies.
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