產品名稱：Recombinant Mouse RANK-L, 25 ug 產品貨號：eBioscience 14-8612-80 產品規(guī)格：25 ug Mouse RANK Ligand Recombinant Protein Also known as: RANKL, TRANCE, Receptor Activator of Nuclear Factor kappa B Ligand, Osteoprotegerin ligand, OPGL, ODF, Osteoclast Differentiation Factor RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8612 Cat. No. Size 14-8612-62 5 ug 14-8612-80 25 ug Description: RANK Ligand (Receptor Activator for Nuclear Factor κB Ligand), also known as TNF-related activation-induced cytokine (TRANCE), along with RANK are members of the TNF superfamily. RANK-L can be found as a soluble protein expressed by activated T lymphocytes, which plays a role in dendritic cell maturation. In addition it has also been shown to be cleaved by TACE (TNF-α convertase) releasing an ectodomain variant of the cell bound form. Lastly RANK-L is expressed as a Type II transmembrane protein expressed by osteoblast lineages. The receptor RANK, located on osteoclastic and dendritic cells can recognize all forms of RANK-L. RANK-L plays a critical role in bone development and mineralization. High levels of RANK-L have been associated with degenerative bone diseases.
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