產(chǎn)品名稱：Human CCL21 (6CKine) Recombinant Protein Purified, 25 ug 產(chǎn)品貨號(hào)：eBioscience 14-8214-80 產(chǎn)品規(guī)格：25 ug Human CCL21 (6CKine) Recombinant Protein Also known as: C-C Motif Chemokine 21, Exodus-2 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8214 Cat. No. Size 14-8214-62 5 ug 14-8214-80 25 ug Description: CCL21, also known as 6Ckine, is a member of the CC- subfamily of chemokines. It is most closely related to CCL19, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naïve T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.
滬公網(wǎng)安備 31011002002623號(hào)
