產(chǎn)品名稱：anti-mouse SLP-76 Purified MS76 25 ug 產(chǎn)品貨號(hào)：eBioscience 14-7761-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse SLP-76 Purified Also known as: SLP76, SLP-76 tyrosine phosphoprotein, Lymphocyte cytosolic protein 2, LCP2 Clone: MS76 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-7761 Cat. No. Size 14-7761-80 25 ug Description: The MS76 antibody reacts with mouse SLP-76. SLP-76 (SH2 domain-containing leukocyte protein of 76 kD) has also been described as lymphocyte cytosolic protein 2 (LCP2 ) and 76-kDa phosphoprotein (pp76 ). SLP-76 is a cytosolic adaptor protein expressed in several cell types of hematopoietic origin. SLP-76 associates with a number of additional molecules and is required for coupling receptor ligation with more distal signaling events in immature thymocytes, mature T cells, platelets, and mast cells. SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
滬公網(wǎng)安備 31011002002623號(hào)
