產品名稱：anti-mouse/human/rat PARP Purified C2-10 50 ul
產品貨號：eBioscience 14-6666-92
產品規格：50 ul
Anti-PARP Purified
Also known as: Poly-ADP-Ribose-Polymerase-1
Clone: C2-10
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-6666
Cat. No. Size
14-6666-92  50 uL 
Description: The C2-10 antibody reacts with mouse and human PARP; the antibody was generated against bovine PARP (Poly-ADP-ribose Polymerase-1). PARP is a 116 kDa nuclear chromatin-associated enzyme that catalyzes the transfer of ADP-ribose units from NAD+ to nuclear proteins such as topoisomerases, histones, and PARP. Following DNA damage, catalytic activity of PARP is increased in nonapoptotic cells. It has been suggested that PARP plays an important role in mediating normal cellular response to DNA damage. PARP is also a target of the protease activity of caspases involved in apoptosis. C2-10 detects both the full-length (116 kDa) and the cleaved (85 kDa) forms of PARP.

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