產(chǎn)品名稱：anti-human/mouse/rat FLIP (N-terminus) Purified Polyclonal 50 ug 產(chǎn)品貨號：eBioscience 14-6205-81 產(chǎn)品規(guī)格：50 ug Anti-FLIP Purified Also known as: CASH, CASP8AP1, CLARP, Casper, FLAME, MRIT, Usurpin, c-FLIP, CFLAR, CASP8, FADD-like apoptosis regulator Clone: Polyclonal RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6205 Cat. No. Size 14-6205-63 10 ug 14-6205-81 50 ug Description: The polyclonal antibody reacts with human, mouse, and rat FLIP (N-terminus); the antibody was raised against amino acid 2-18 of human FLIP and recognizes all FLIP variants of human, mouse and rat origin. Cellular FLIP, FLICE-like inhibitory proteins, exist as a long c-FLIPL and a short c-FLIPS splice variant, both of them capable of protecting cells from death receptor-mediated apoptosis. FLIP proteins structurally resemble caspase-8 except that they lack proteolytic activity. FLIP variants are highly expressed in tumor cells, T lymphocytes and healthy, but not injured, myocytes; this suggests a critical role of FLIP as endogenous modulators of apoptosis. FLIP are recruited to the death-inducing signaling complex and interfere with the recruitment of caspase-8.
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