產(chǎn)品名稱：Anti-Mouse CD254 (RANK Ligand) Purified (IK22/5) 100 ug 產(chǎn)品貨號：eBioscience 14-5952-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse CD254 (RANK Ligand) Purified Also known as: OPGL, TNFSF11, ODF Clone: IK22/5 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5952 Cat. No. Size 14-5952-81 50 ug 14-5952-82 100 ug Description: The IK22/5 monoclonal antibody reacts with mouse TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-κB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation and is expressed abundantly by mouse T cells not B cells in mouse thymus and lymph nodes. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.
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