產(chǎn)品名稱：anti-mouse/human Integrin beta7 Purified FIB504 100 ug 產(chǎn)品貨號：eBioscience 14-5867-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse Integrin beta 7 Purified Also known as: Integrin b7, ITGB7 Clone: FIB504 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5867 Cat. No. Size 14-5867-80 25 ug 14-5867-82 100 ug Description: The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7. Integrin beta 7 is a 130 kD glycoprotein which associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha 4 beta 7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alpha E beta 7 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.
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