產(chǎn)品名稱：Purified anti-mouse ISG-15 (ISG15) 100 ug 產(chǎn)品貨號：eBioscience 14-5857-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse ISG15 Purified Also known as: ISG-15 Clone: 3C2 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5857 Cat. No. Size 14-5857-80 25 ug 14-5857-82 100 ug Description: This 3C2 monoclonal antibody reacts with mouse interferon stimulated gene-15 (ISG-15), a 15kDa ubiquitin-like protein (UBL) and cytokine. ISG-15 is translated as a precursor that is subsequently activated by an E1 enzyme, conjugated by an E2 enzyme via the C-terminal LRLRGG motif and ligated by an E3 ligase. The activity of ISG-15 is dependent on its modification of target proteins at specific lysine residues. Several viruses utilize ISG-15 and ubiquitin deconjugating proteases, while influenza B protein NS1 has been shown to specifically bind ISG-15 thereby blocking its conjugation. In addition to its role as a protein modification, ISG-15 is secreted by monocytes and lymphocytes in response to IFNα, β, or γ, as well as influenza B virus. In this role as cytokine, it has been shown to induce secretion of IFNγ and support NK cell proliferation and cytolytic activity.
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